{"id":7357,"date":"2022-04-23T17:02:00","date_gmt":"2022-04-23T15:02:00","guid":{"rendered":"https:\/\/www.nexmif.it\/uncategorized\/nexmif-kidlia\/"},"modified":"2022-05-30T09:54:56","modified_gmt":"2022-05-30T07:54:56","slug":"nexmif-kidlia","status":"publish","type":"post","link":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/","title":{"rendered":"NEXMIF\/KIDLIA: towards an animal model"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Prof. Heng-Ye Man<\/strong>, head of the Department of Biology at Boston University – Massachusetts USA<\/strong>, and his research group have been studying the correlation between the NEXMIF \/ KIDLIA gene and autism spectrum disorders (ASD) for years. In this 2020 study, they successfully created a mouse model to observe autism and intellectual disability linked to Nexmif mutations.\u00a0<\/p>

Nexmif knock out mice show autistic-like behaviors, including deficits in social interaction, tendency to repetitive self-cleaning and difficulties in communication, learning and memory. Neurons from the animal model demonstrate reduced synapse density and suppression in synaptic transmission: the NEXMIF gene plays an important role in synapse development and functioning. This means that an animal model can finally be considered and used to further study Nexmif-dependent neurodevelopmental disorders.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\n\t\t\t\t\t\t
\n\t\t\t\t\n\t\t\t\t<\/i>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNEXMIF\/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function <\/i>\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Prof. Heng-Ye Man, head of the Department of Biology at Boston University – Massachusetts USA, and his research group have been studying the correlation between the NEXMIF \/ KIDLIA gene and autism spectrum disorders (ASD) for years. In this 2020 study, they successfully created a mouse model to observe autism and intellectual disability linked to […]<\/p>\n","protected":false},"author":3,"featured_media":7988,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,91],"tags":[],"class_list":["post-7357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pubblicazioni-scientifiche","category-scientific-journals"],"yoast_head":"\nNEXMIF\/KIDLIA: towards an animal model - Unione Italiana Nexmif<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NEXMIF\/KIDLIA: towards an animal model - Unione Italiana Nexmif\" \/>\n<meta property=\"og:description\" content=\"Prof. Heng-Ye Man, head of the Department of Biology at Boston University – Massachusetts USA, and his research group have been studying the correlation between the NEXMIF \/ KIDLIA gene and autism spectrum disorders (ASD) for years. In this 2020 study, they successfully created a mouse model to observe autism and intellectual disability linked to […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/\" \/>\n<meta property=\"og:site_name\" content=\"Unione Italiana Nexmif\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-23T15:02:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-05-30T07:54:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.nexmif.it\/wp-content\/uploads\/2022\/04\/nexmif_modello_animale-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1440\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"tecnico\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"tecnico\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/\"},\"author\":{\"name\":\"tecnico\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#\\\/schema\\\/person\\\/d7d9d7ada6f302c812dbc5408405c955\"},\"headline\":\"NEXMIF\\\/KIDLIA: towards an animal model\",\"datePublished\":\"2022-04-23T15:02:00+00:00\",\"dateModified\":\"2022-05-30T07:54:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/\"},\"wordCount\":145,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.nexmif.it\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/nexmif_modello_animale-scaled.jpg\",\"articleSection\":[\"Pubblicazioni scientifiche\",\"Scientific journals\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/\",\"url\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/\",\"name\":\"NEXMIF\\\/KIDLIA: towards an animal model - Unione Italiana Nexmif\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.nexmif.it\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/nexmif_modello_animale-scaled.jpg\",\"datePublished\":\"2022-04-23T15:02:00+00:00\",\"dateModified\":\"2022-05-30T07:54:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.nexmif.it\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/nexmif_modello_animale-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/www.nexmif.it\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/nexmif_modello_animale-scaled.jpg\",\"width\":2560,\"height\":1440,\"caption\":\"Abstract Genetics Disease - 3d rendered image. Hologram view. SEM (TEM) macroscope image. DNA mutations. Vexas disease. Medicine Healthcare research concept. X chromosomes objects.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/scientific-journals\\\/nexmif-kidlia\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"NEXMIF\\\/KIDLIA: towards an animal model\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/\",\"name\":\"Unione Italiana Nexmif\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#organization\",\"name\":\"Unione Italiana Nexmif\",\"url\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.nexmif.it\\\/wp-content\\\/uploads\\\/2015\\\/12\\\/logo-big_w.png\",\"contentUrl\":\"https:\\\/\\\/www.nexmif.it\\\/wp-content\\\/uploads\\\/2015\\\/12\\\/logo-big_w.png\",\"width\":489,\"height\":202,\"caption\":\"Unione Italiana Nexmif\"},\"image\":{\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.nexmif.it\\\/en\\\/#\\\/schema\\\/person\\\/d7d9d7ada6f302c812dbc5408405c955\",\"name\":\"tecnico\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/14e5085ad1e6f41563871ce4c96366866cac3d43b224085e5aa5b43a8646099a?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/14e5085ad1e6f41563871ce4c96366866cac3d43b224085e5aa5b43a8646099a?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/14e5085ad1e6f41563871ce4c96366866cac3d43b224085e5aa5b43a8646099a?s=96&d=mm&r=g\",\"caption\":\"tecnico\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"NEXMIF\/KIDLIA: towards an animal model - Unione Italiana Nexmif","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/","og_locale":"en_US","og_type":"article","og_title":"NEXMIF\/KIDLIA: towards an animal model - Unione Italiana Nexmif","og_description":"Prof. Heng-Ye Man, head of the Department of Biology at Boston University – Massachusetts USA, and his research group have been studying the correlation between the NEXMIF \/ KIDLIA gene and autism spectrum disorders (ASD) for years. In this 2020 study, they successfully created a mouse model to observe autism and intellectual disability linked to […]","og_url":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/","og_site_name":"Unione Italiana Nexmif","article_published_time":"2022-04-23T15:02:00+00:00","article_modified_time":"2022-05-30T07:54:56+00:00","og_image":[{"width":2560,"height":1440,"url":"https:\/\/www.nexmif.it\/wp-content\/uploads\/2022\/04\/nexmif_modello_animale-scaled.jpg","type":"image\/jpeg"}],"author":"tecnico","twitter_card":"summary_large_image","twitter_misc":{"Written by":"tecnico","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/#article","isPartOf":{"@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/"},"author":{"name":"tecnico","@id":"https:\/\/www.nexmif.it\/en\/#\/schema\/person\/d7d9d7ada6f302c812dbc5408405c955"},"headline":"NEXMIF\/KIDLIA: towards an animal model","datePublished":"2022-04-23T15:02:00+00:00","dateModified":"2022-05-30T07:54:56+00:00","mainEntityOfPage":{"@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/"},"wordCount":145,"commentCount":0,"publisher":{"@id":"https:\/\/www.nexmif.it\/en\/#organization"},"image":{"@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/#primaryimage"},"thumbnailUrl":"https:\/\/www.nexmif.it\/wp-content\/uploads\/2022\/04\/nexmif_modello_animale-scaled.jpg","articleSection":["Pubblicazioni scientifiche","Scientific journals"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/","url":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/","name":"NEXMIF\/KIDLIA: towards an animal model - Unione Italiana Nexmif","isPartOf":{"@id":"https:\/\/www.nexmif.it\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/#primaryimage"},"image":{"@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/#primaryimage"},"thumbnailUrl":"https:\/\/www.nexmif.it\/wp-content\/uploads\/2022\/04\/nexmif_modello_animale-scaled.jpg","datePublished":"2022-04-23T15:02:00+00:00","dateModified":"2022-05-30T07:54:56+00:00","breadcrumb":{"@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/#primaryimage","url":"https:\/\/www.nexmif.it\/wp-content\/uploads\/2022\/04\/nexmif_modello_animale-scaled.jpg","contentUrl":"https:\/\/www.nexmif.it\/wp-content\/uploads\/2022\/04\/nexmif_modello_animale-scaled.jpg","width":2560,"height":1440,"caption":"Abstract Genetics Disease - 3d rendered image. Hologram view. SEM (TEM) macroscope image. DNA mutations. Vexas disease. Medicine Healthcare research concept. X chromosomes objects."},{"@type":"BreadcrumbList","@id":"https:\/\/www.nexmif.it\/en\/scientific-journals\/nexmif-kidlia\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.nexmif.it\/en\/"},{"@type":"ListItem","position":2,"name":"NEXMIF\/KIDLIA: towards an animal model"}]},{"@type":"WebSite","@id":"https:\/\/www.nexmif.it\/en\/#website","url":"https:\/\/www.nexmif.it\/en\/","name":"Unione Italiana Nexmif","description":"","publisher":{"@id":"https:\/\/www.nexmif.it\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.nexmif.it\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.nexmif.it\/en\/#organization","name":"Unione Italiana Nexmif","url":"https:\/\/www.nexmif.it\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.nexmif.it\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.nexmif.it\/wp-content\/uploads\/2015\/12\/logo-big_w.png","contentUrl":"https:\/\/www.nexmif.it\/wp-content\/uploads\/2015\/12\/logo-big_w.png","width":489,"height":202,"caption":"Unione Italiana Nexmif"},"image":{"@id":"https:\/\/www.nexmif.it\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.nexmif.it\/en\/#\/schema\/person\/d7d9d7ada6f302c812dbc5408405c955","name":"tecnico","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/14e5085ad1e6f41563871ce4c96366866cac3d43b224085e5aa5b43a8646099a?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/14e5085ad1e6f41563871ce4c96366866cac3d43b224085e5aa5b43a8646099a?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/14e5085ad1e6f41563871ce4c96366866cac3d43b224085e5aa5b43a8646099a?s=96&d=mm&r=g","caption":"tecnico"}}]}},"_links":{"self":[{"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/posts\/7357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/comments?post=7357"}],"version-history":[{"count":0,"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/posts\/7357\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/media\/7988"}],"wp:attachment":[{"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/media?parent=7357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/categories?post=7357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nexmif.it\/en\/wp-json\/wp\/v2\/tags?post=7357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}